Nationally, narratives of opioid overdose as a predominantly White suburban crisis tell only a partial story, overshadowing the importance of local geosocial contexts in producing overdose disparities in marginalized and underserved communities. The goal of this project is to develop an innovative Ethno-Geographic Information System (EGIS) combining ethnography with spatial analytics to characterize opioid overdose and guide resource allocation and research to address overdose disparities in underserved communities. Our research will provide an innovative new method, EGIS, to serve as a foundation for developing and testing community-level interventions to reduce overdose incidence and mortality in subsequent R01 grant proposals, and will provide a new tool for use by communities around the country to refine and optimally target efforts to reduce opioid overdose disparities.